Dr. Grandel produces Ampoules since 1947. Thus, the production machines are fine tuned to perfection which results in a high quality ampoule bottle. They do not shatter and can only be ‘popped’ open at the indicated dot. They are ‘one-shot’ cocktails for the skin! Nothing to be sipped on for days 😉 Home use: Best is to apply half of it to chest, neck and face, massage it in and immediately massage in the second half. Facial protocol: Massage in the full amount before you apply the mask OR apply half before the mask and the other half before you apply moisturizer.